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Likewise, GLP-1(9-36)amide could reverse AD-related alterations in hippocampal synaptic plasticity and memory deficits, but did not alter levels of APP and A in APP/PS1 mice (218)
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It plays a crucial role in glucose homeostasis by: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [8] [9] Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates postprandial glucose excursions Promoting satiety through actions on appetite centres in the brain GLP-1 receptor agonists mimic these physiological effects but with extended half-lives, allowing for once-weekly or once-daily administration
14 and Supplementary Table 1)
De Flora, S., C
